I alpha-hydroxycholecalciferol: a treatment of renal bone disease.

Whole-body in-vivo neutron activation analysis in assessing treatment of renal osteodystrophy with 1-alpha-hydroxycholecalciferol.

Four selected adults with different patterns of osteodystrophy receiving regular dialysis were treated with 1-alpha-hydroxycholecalciferol (1-alpha-OHD3) 0-5-2 mug/day for 10 to 12 months. In two patients, one with osteitis fibrosa and the other with osteomalacia, significant biochemical, radiological, and histological improvements occurred, and total body calcium measured by in-vivo neutron ac...

Effect of 1-alpha-hydroxycholecalciferol on magnesium metabolism in chronic renal failure.

Effect of 1-alpha-hydroxycholecalciferol on magnesium metabolism in chronic renal failure Vitamin D derivatives and analogues are increasingly being used to treat bone disease in chronic renal failure but their effects on magnesium metabolism have not been fully documented. The use of 1-oc-hydroxycholecalciferol (1-m-OHDD) in chronic renal failure, however, may be associated with a special risk...

Effect of low dose 1 alpha-hydroxycholecalciferol on glomerular filtration rate in moderate renal failure.

Serial measurements of 51Cr edetic acid clearance were made over a period of one year in two groups of 8 children, in a double blind trial of 1 alpha-hydroxycholecalciferol (10 ng/kg/day) and calciferol (670 ng/kg/day). Glomerular filtration rate (GFR) at the beginning of the trial was 20-50 ml/min/1.73 m2; it rose in the children given 1 alpha-hydroxycholecalciferol (group A) after 6 months bu...

renal bone disease among patients with esrd

ACE I/D and MMP-7 A-181G variants and the risk of end stage renal disease

The variants of angiotensin converting enzyme (ACE) and matrix metalloproteinases (MMPs) genes might be involved in the pathogenesis of end stage renal disease (ESRD) and hypertension. We studied the ACE insertion/deletion (I/D) and MMP-7 A-181G variants in 99 unrelated ESRD patients and 117 individuals without renal complications from Western Iran with Kurdish ethnic background. The frequency ...